Ailments

Our immune system is designed to identify and kill anything that is considered as “foreign” to our body. This plays a very crucial role in preserving the body against invading organism. In auto-immunity, the body starts fighting against its own tissues thereby destroying it.

One of the major uses of medical cannabis in the US is cancer related pain and chemotherapy related side-effects. Those on medical cannabis show better tolerance to chemotherapy. Studies have shown that cannabis significantly reduces chemotherapy induced nausea and vomiting (CINV).

CKD is a clinical condition, where kidney function slowly impairs causing build-up of toxic metabolites. Two main causes of CKD are chronic hypertension and diabetes. CKD is often slow progressing and can take up to 15-20 years to show symptoms.

For all practical purposes, there are two types of diabetes (type-1 and type-2). Type 1 is a condition where pancreatic cells are destroyed (due to auto-immune reaction) and insulin cannot be produced. Such patients have to be on insulin life-long.

ECS and cannabinoids modulate the GIT through CB1 and CB2 receptors and via other pathways. In the Gastrointestinal system (GIT), it modulates peristalsis (intestinal movement), secretions, inflammation and pain. It also modulates appetite and energy utilization (metabolism).

Human studies have also shown that CBD is protective against the psychotic effects of THC in higher doses especially in long-term users.

Multiple studies on animals and clinical trials have shown neuroprotective effects of cannabinoids. ECS is a retrograde signalling system which simply put means that it works on negative feedback.

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One of the major symptoms that cannabis (smoking or the oral) is used worldwide in treating "chronic pain". Cannabinoids (via ECS and other pathways) modulate pain-perception and heal tissue injury. There are 3 types of pain: Nociceptive pain, neuropathic pain and central pain.

Skin biology is modulated distinctly by the ECS. CBD, in particular, has gathered much interest lately because pre-clinical studies have shown promising results in conditions like psoriasis, eczema, inflammatory condition and pruritis.